王玥 博士后

研究概述

主要聚焦抑郁障碍等情感障碍的致病及干预机制研究。基于膜片钳、光纤记录、光遗传、化学遗传等技术，结合常规分子生物学手段，阐述情感障碍的神经环路机制，为抑郁障碍治疗新靶点提供理论基础。

代表性文章

1. Yue Wang#, Xiangyu Chen#, Zhi Chen, Heming Yu, Yu Tian, Yong He, Ke Cheng*, Peng Xie*. Disturbances of phosphatidylcholines metabolism in major depressive disorder, CNS Spectrums, 2023 Jan 17;1-9.

2. Yue Wang#, Yan Li#, Zhonghao Wu#, Zhi Chen#, Heming Yu, Yong He, Yu Tian, Tianlan Lan, Mengge Bai, Xiangyu Chen, Ke Cheng*, Peng Xie*. Ferritin disorder in the plasma and hippocampus associated with major depressive disorder. Biochemical and Biophysical Research Communications, 2021, 553:114-118.  

3. Yue Wang, Liming Liu, Hengsheng Chen, Li Cheng, Li Jiang*. Influence of the epileptiform discharge microenvironment on the differentiation of oligodendrocyte precursor cells. Brain Research, 2018, 1679:53–63.

4. Xi Chen#, Tianlan Lan#, Yue Wang#, Yong He#, Zhonghao Wu, Yu Tian, Yan Li, Mengge Bai, Wei Zhou, Hanping Zhang, Ke Cheng, Peng Xie*. Entorhinal cortex-based metabolic profiling of chronic restraint stress mice model of depression. Aging (Albany NY),2020, 12(3):3042-3052.

5. Yu Tian#, Zhonghao Wu#, Yue Wang#, Chong Chen#, Yong He, Tianlan Lan, Yan Li, Mengge Bai, Heming Yu, Xiangyu Chen, Zhi Chen, Ke Cheng*, Peng Xie*. Alterations of neurotransmitters and related metabolites in the habenula from CUMS-susceptible and -resilient rats. Biochem Biophys Res Commun,2021, 534:422-428.  

6. Xi Chen#, Yong He#, Yu Tian#, Yue Wang#, Zhonghao Wu, Tianlan Lan, Haiyang Wang, Ke Cheng*, Peng Xie*. Different Serotypes of Adeno-Associated Virus Vector- and Lentivirus-Mediated Tropism in Choroid Plexus by Intracerebroventricular Delivery. Hum Gene Ther,2020, 31(7-8):440-447.  

7. Tianlan Lan#, Mengge Bai#, Xiangyu Chen#, Yue Wang#, Yan Li#, Yu Tian, Yong He, Zhonghao Wu, Heming Yu, Zhi Chen, Chong Chen, Yaping Yu, Ke Cheng*, Peng Xie*. iTRAQ-based proteomics implies inflammasome pathway activation in the prefrontal cortex of CSDS mice may influence resilience and susceptibility. Life Sci,2020,262:118501.