李文霞 副教授

重庆医科大学附属第一院，国家卫健委功能性脑疾病诊治重点实验室，高级实验师。

研究方向

多年从事无菌小鼠的研究工作，主要方向是利用无菌小鼠探索菌群与疾病关系的研究，目前基于解析机体自身基因组功能与肠道菌群宏基因组功能的相互关系，形成了无菌小鼠人工哺乳、遗传工程小鼠无菌化等模型动物制备体系，建成了一定规模的无菌小鼠平台，参与关于菌群与神经类疾病、代谢性疾病、免疫性疾病等相关性研究。

代表性文章

1. Li W, Yan H, Hui D, Yi X, Gut microbiota can transfer fiber characteristics and lipid metabolic profiles of skeletal muscle from pigs to germ-free mice. Scientific Reports, 2016, 6:31786.

2. Zheng P,  Zeng B, Zhou C, Liu M, Fang Z, Xu X, Zeng L, Chen J, Fan S, Du X, Zhang X, Yang D, Yang Y, Meng H, Li W, N D Melgiri, J Licinio, Wei H, Xie P, Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism, Molecular Psychiatry, 2016, 21(6).

3. Wang H, Liu L, Rao X, Chai T, Zeng B, Zhang X, Yu Y, Zhou C, Pu J, Zhou W, Li W, Zhang H, Wei H, Xie P, Commensal Microbiota Regulation of Metabolic Networks During Olfactory Dysfunction in Mice, Neuropsychiatr Dis Treat, 2020, 2020(16): 761-769.

4. Liu L, Wang H, Rao X, Yu Y, Li W, Zheng P, Zhao L, Zhou C, Pu J, Yang D, Fang L, Ji P, Song J, Wei H, Xie P, Comprehensive analysis of the lysine acetylome and succinylome in the hippocampus of gut microbiota-dysbiosis mice, Journal of Advanced Research, 2021, 2021(30): 27-38.

5. Yu Y, Wang H, Rao X, Liu L, Zheng P, Li W, Zhou W, Chai T, Ji P, Song J, Wei H, Xie P, Proteomic Profiling of Lysine Acetylation Indicates Mitochondrial Dysfunction in the Hippocampus of Gut Microbiota-Absent Mice, Front Mol Neurosci. 2021, 14: 594332.